Basic information of drug: DB06738
| Drug id | DB06738 |
| Drug name | Ketobemidone |
| Description | Ketobemidone is a powerful opioid analgesic. It also has some NMDA-antagonist properties. This makes it useful for some types of pain that don't respond well to other opioids. The most commonly cited equalisation ratio for analgesic doses is 25 mg of ketobemidone hydrobromide to 60 mg of morphine hy... |
| State | solid |
| Cas number | 469-79-4 |
| Synonyms | Cetobemidona Cetobemidone Cetobemidonum |
| Sequences | None |
| Indication | For the treatment of all types of severe pain, such as postoperative, cancer, kidney stones and fractures. |
| Pharmacodynamics | None |
| Mechanism of action | Ketobemidone (Cliradon, Ketogan, Ketodur, Cymidon, Ketorax, &c.) is a powerful opioid analgesic. It also has some NMDA-antagonist properties. This makes it useful for some types of pain that don't respond well to other opioids. The most commonly cited equalisation ratio for analgesic doses is 25... |
| Metabolism | Ketobemidone is mainly metabolised by conjugation of the phenolic hydroxyl group, and by N-desmethylation. Only about 13-24% is excreted unchanged after iv. administration. |
| Toxicity | Base: Rat Intravenous LD50: 10 mg/kg; Mouse Intravenous LD50: 14 mg/kg. Hydrochloride salt: Rat Oral LD50: 215 mg/kg; Rat Intravenous LD50: 40 mg/kg |