Basic information of drug: DB00098
| Drug id | DB00098 |
| Drug name | Antithymocyte immunoglobulin (rabbit) |
| Description | Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of actio... |
| State | liquid |
| Cas number | 308067-60-9 |
| Synonyms | Anti-human thymocyte immunoglobulin, rabbit Anti-T-lymphocyte immune globulin, rabbit Anti-thymocyte globulin (rabbit) Anti-thymocyte globulin rabbit Antithymocyte immunoglobulin Lapine T-lymphocyte immune globulin |
| Sequences | None |
| Indication | For prevention of renal transplant rejection |
| Pharmacodynamics | Antithymocyte Globulin (ATG) is a concentrated anti-human T-lymphocyte immunoglobulin preparation derived from rabbits after immunization with a T-lympoblast cell line. ATG is an immunosuppressive product for the prevention and treatment of acute rejection following organ transplantation. ATG reduce... |
| Mechanism of action | Binds to multiple, T-cell specific antigens leading to T-lymphocyte cell death via complement mediated cytotoxicity or apoptosis. |
| Metabolism | Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production. |
| Toxicity | Not known whether ATG (rabbit) distributes into human milk; however, other immunoglobulins are distributed into human milk. |